IVF: Approach to Selecting the Best Embr yos for Transfer to the Uterus. I wanted to point out thestandard deviationof this data is large, roughly 30% for each group. Neal et al. December 2015: IVF Retrieval #3 - 31 retrieved, 24 mature, 21 fertilized w/ICSI, 8 frozen, 3 normal. All we can tell you is that this particular embryo has or doesnt have the condition. Inconclusive or No Result biopsies may require a second round of biopsy aka a rebiopsy. PGD 2 out of 11 embryos are normal and put back in. Our RE said that any changes in supplements will take at least 3 months to have an effect? That is why we always recommend that you get some form of non-invasive prenatal aneuploidy assessment in early pregnancy at the very least. On average, women in their late 20s had four euploid embryos (day 3 or day 5) per cycle, but this number decreased linearly (R2 R 0.983) after 35 years of age. Start taking baby aspirin. Most of us have 46 chromosomes. In two of these embryos all reanalysed cells were normal diploid, i.e. I totally understand your fear, but I think you can be more optimistic. I am 32 with dor and poor egg quality; DH has MFI. PGT does not guarantee that you have healthy embryos. I'm pretty sure they dispose immediately, as that is what I was told by my office. Oftentimes, we will recommend that you see a genetic counselor to understand the risks involved with using a mosaic. Thats a major benefit and source of assurance to women who have suffered many miscarriages prior to IVF with PGS. PGD or PGS, thus, is the smart thing to do so much that we have coined the term SMART IVF to describe them. Bleeding During IVF - What's Normal and What Isn't? During this process, as many eggs as possible will be collected. It occurs in 30% of all conception and 10% of all clinical pregnancies. https://alexroblesmd.com/wp-content/cache/breeze-minification/js/breeze_d8b9ac1cac0e674c1a0b0961093927ba.js, https://alexroblesmd.com/wp-content/cache/breeze-minification/js/breeze_e709f6277bbec007e5a021ac9cdc419b.js, https://alexroblesmd.com/wp-content/cache/breeze-minification/js/breeze_d6638419dc0ffa7ebd981022572d700a.js, https://alexroblesmd.com/wp-content/cache/breeze-minification/js/breeze_b410f7096d4a966b622520512b7f5e7d.js. For female above 45 years of age. 79% of the eggs studied from women 40-45 years old were found to have an abnormal spindle appearance and at least one chromosome displaced from proper alignment. Consult with your doctor before making any treatment changes. One such screening is PGS (preimplantation genetic screening) and PGD (preimplantation genetic diagnosis). As displayed in the figure below, the percentage of genetically abnormal embryos increases significantly after women reach the age of 35. eggs will be fertilized with sperm on that day, make it to the blastocyst stage on Days 5, 6, or 7. Thanks for your encouragement! July 20, 2016: FET #3. We repeated IVF /PGS and got 2 out of 9 normal embryos. I went to a good clinic in Toronto. So that puts us actually below 50% normal. Underlined Is what I will be adding. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. The screening method and clinics reputation for careful handling of embryos factors into the success rates. Bradley et al. Another way is by evaluating birth defects and genetic disorders. PGT-A for Recurrent Miscarriage and IVF Failure, Why Women Become Surrogates and Egg Donors. Fertil Steril. 4 came out normal. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). However, a larger biopsy is taken, it can potentially harm the embryo. PGS/PGT-A testing prices can range between $4,000 and $10,000 for screening on eight embryos. Good luck everyone. Hopefully, one or more embryos will make it to the blastocyst stage on Days 5, 6, or 7. https://www.google.com/amp/s/amp.theguardian.com/science/2017/aug/02/deadly-gene-mutations-removed-from-human-embryos-in-landmark-study. Determining IVF with PGS success rates is possible, but contextually it's important to realize that without it, embryos that have chromosomal abnormalities can be transferred fresh, or frozen for later transfer. hbspt.cta._relativeUrls=true;hbspt.cta.load(389004, '2f6d41b7-5446-4753-b5dc-09cba35bf859', {"useNewLoader":"true","region":"na1"}); Dr. Karande is Board Certified in the specialty of Obstetrics and Gynecology as well as the subspecialty of Reproductive Endocrinology and Infertility. Good luck to you!! PGS aka PGT (preimplantation genetic testing) is a method of screening embryos for genetic mutations before implanting them into your uterus. So here is what I will be taking. And thank you, your story has given me hope :). Sometimes you may have something called a translocation or inversion mutation where parts of two different chromosomes are exchanged or even missing. But actually, it would be 3/7 that were normal, according to how the stats are actually calculated - those that didn't make it to blast were abnormal, most likely. doi: 10.1016/j.fertnstert.2019.07.1346. Lost pregnancy just past 6 weeks. Dr. Alex Robles is a Spanish-speaking Latino-American Reproductive Endocrinologist and Infertility specialist in New York City, and a board-certified OBGYN. PGS test results are available within 7-10 days. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Epub 2019 Sep 21. The Southern California Center for Reproductive Medicine in Orange County serving Aliso Viejo, Costa Mesa, Laguna Beach, Newport Beach, Mission Viejo, Huntington Beach, Long Beach, Torrance Manhattan Beach, Dana Point, San Clemente, Rancho Santa Margarita, Irvine, Anaheim, Santa Monica, Beverly Hills, Los Angeles, San Diego, Yorba Linda, Fullerton, Orange, Fountain Valley, Corona, Palos Verdes, Oceanside, Riverside, Redondo Beach, Murrieta, Temecula, Laguna Hills. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. A very high percentage of abnormal PGS results are caused by an abnormal number of chromosomes within the mature egga significant age-dependent event. the cell biopsied during the PGS procedure was the only abnormal cell. The technical term used for this process is preimplantation genetic screening (PGS) or pre-implantation genetic diagnosis (PGD). Typically, only genetically normal embryos will be kept for transfer. I almost gave up through this process (still can't believe I didn't!). The world says give up! These forums were a critical source of support when we were in the midst of fertility treatments, and even now as I struggle with accepting that it is over. Capalbo et al. My advice - don't give up, and make sure to advocate for yourself in your treatment plan. But that is on a per-transfer basis. This is useful for detecting common disorders like Down syndrome (which is trisomy 21) and trisomies 13 and 18. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. The day following your retrieval, we will check to see if fertilization successfully took place. STOP EVERYTHING. BFN. We sent 6 embryos for transfer and none were normal (various abnormalities in different chromosomes). As women age, the likelihood of an irregular chromosome count only increases. (2018)found a slight reduction inlive birth ratecompared to single biopsied embryos (50% vs 58%), but this was notstatistically significant. However, if it does not, patients and their physicians will need to determine whether or not to keep the embryo or discard it. We opted to not know the gender. In women aged 27 to 35 years, the median proportion of euploid embryos in each cycle remained constant at approximately 35% in day-3 biopsies and approximately 55% in day-5 biopsies, but it decreased rapidly after age 35. I suggest reading or listening to the book on improving egg quality "It Starts with an Egg". My husband and I are both 34. All three were boys. PGT-M (preimplantation genetic testing for monogenic diseases) takes it one step deeper and screens for specific genetic conditions that affect individual genes. We sent 8 to be PGS tested and 7 came back normal. I also try to buy the Jarrow brand as I worked for them up to last Sept before I quit to prep for IVF process. The rate of aneuploidy begins to increase significantly after the age of 40 and drops below 30% in women over the age of 41. Meaning that if you begin a cycle, retrieve eggs, produce embryos, then do PGS testing, and at least one embryo comes back normal, 60 - 70% of the time it will lead to a live birth. He is a Fellow of the American College of Obstetricians and Gynecologists and Member of the American Society for Reproductive Medicine. Appointment on June 20th, 2013. For some women going through IVF, the choice of having PGS performed on their embryos is a no-brainer. Humans have 23 pairs of chromosomes- equalling 46. Nearly 60% are over 42 and nearly half are over 44. After age 35, the average number of euploid embryos decreased sharply, with a strong inverse linear relationship with age in both day-3 and day-5 embryos (R 2 = 0.983 and 0.991, respectively; Fig. PGT-M on the other hand tests for a specific genetic condition that may run in your family. May 19, 2016: FET #2 of 1 blastocyst. IVFauthority.com does not provide medical advice. Many couples opt for PGS to provide a higher chance of a successful pregnancy and live birth. Unfortunately, this embryo split and I miscarried at 7.5 weeks. Therefore, the IVF with PGS success rates should be higher than without it. Second,. In our study, when the possibility of finding at least one euploid embryo for transfer was evaluated according to maternal age, the percentage of cycles with at least one transferable embryo decreased steadily from age 35 (p < 0.001), with a continual decrease until 39 and a steep decline from age 40 onward (p < 0.001) which became even steeper . I have been taking most for a few months, but will add a couple more to see if it makes a difference. He also answers questions in his private Facebook group. In all those success rate there will always be a 20%, 30%, 40% chance of failure, that may have nothing to do with anything. As expected, the percentage of women with at least one normal embryo declines with increasing age. Out of those 6, three were normal. Common conditions it can screen for include cystic fibrosis, spinal muscular atrophy, Tay-Sachs disease, thalassemia, sickle cell anemia, Huntingtons disease, BRCA, and much more. However, Dr Esteves cautioned that other factors might also affect the likelihood of obtaining a normal embryo. It had an extra chromosome from the sperm and another from the egg. My acupuncturist seems to be extremely knowledgeable in infertility so that helps. I'm so sorry you're not getting your BFP and I can only imagine that hearing it's a numbers game is not the answer you want, so frustrating! Up to age 40, most women will have at least one normal embryo. We are moving Hi ladies!I had my ER on Sunday and they told me before I left that they got 18 eggs and would call me next day with how many were mature and fertilized. Not exactly! Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). We expected to have at least one. Zhao et al. PGT is an optional test that can benefit women >35 years of age undergoing in vitro fertilization by avoiding the use of an aneuploid embryo. No problems found. I'm now extremely worried that neither of the 2 stick because DH won't agree to another round and I desperately want this baby! 3 failed IUIs, May 2015: IVF#1 - 29 retrieved, 19 mature, 10 fertilized. Fresh versus Frozen Embryo Transfers (FET) Enhance IVF Outcome. Success with PGS normal embryos- how many tries? IVF#2- Sept 2016 (Freeze all/PGS). In women under the age of 35, approximately 60% of embryos will be chromosomally normal. Or they did but they were all aneuploid? Embryo Grading and Success Rates Once fertilized, embryos are graded according to their form and quality. Your email address will not be published. It does not constitute medical advice and does not establish any kind of doctor-client relationship by your use of this website. Who Benefits from PGS/PGD to Increase IVF Success? This educational content is not medical or diagnostic advice. I had no more normal boys left but did have 1 abnormal boy left (mosaic monosomy 6). My age is 43 and DH is 42. A common question we get asked about the process is, How many normal (euploid) embryos will I produce? Demko et al addressed this very issue in a recent publication. started June 26th. ago Hi! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I'm very grateful to have two and I'm going to be very positive about one sticking. More studies need to be done. Hi everyone, we just got PGS results back and I'm a bit shocked. I think that helped it stick. I can't help but think about all these moms that got zero normal results and their story could have turned out like yours. I have a whole page dedicated to mosaic embryos. Starting our IVF journey and we are having a hard time making some decisions. IVF #3 - May 2013. I don't know how quickly these clinics dispose/experiment with embryos like this.. Our first IVF round we ended up with one blastcosyst but unfortunately it ended up being chromosomally abnormal. When we did CCS none of the bad chromosomes were the common ones--if we'd just done PGD to test the common ones, we would have gotten false positives. While this news can be disheartening, it is easier to handle than a miscarriage due to a chromosomal abnormality, or a failed implantation. It is reported to have ~ 95% accuracy. In all her years of medical training, she had never encountered some of the hard truths of female infertility, including the fact that for women older than 42, nearly 90 percent of the embryos they produce are aneuploid. Thank you. A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. What percentage of embryos come back PGS normal? This was my first FET. CoQ10 Ubiquinol not Ubiquinone. DS #1 conceived naturally, born Dec. 1st, 2008 Required fields are marked *. I have been in the Nutraceutical Industry for over 20 yrs and very familiar with most supplements. In addition, there is a small chance that the embryo biopsy can lead to a. I couldn't bear the thought of using my normal ones and never knowing what would have been with the PGS abnormals. turns out intuition was most powerful in this situation. Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. those that have reached the blastocyst stage - makes an ongoing pregnancy more likely. I did PGS testing. My first round we had 12 eggs, 11 were mature and ICSI, 8 fertilized and only 2 made it to day 6 blast. It also depends on what day embryo you have, day 5 - 80% chance of success, day 6 - 70% chance of success, day 7 - 60% chance of success. Logic suggests that by implanting embryos that are known to be normal, the likelihood of miscarriage or failed implantation goes down. What to expect in terms of reliability and success rates. As expected, the percentage of women with at least one normal embryo declines with increasing age. If you do CCS or CGH testing (the type of PGD that's normally done on blasts, which tests all 23 chromosomes), the error rate (false negative or positive) is only about 3%. Wishing you all the best!! We sent 11 for testing and 6 came back normal. 10 mature. I had a consult with RMA in USA (one of the best clinics) and they told me that they never get that kind of a reading 'chaotic profile'. The graph below illustrates what we have discovered. Doctor hinted I might be cleared to go back to IVF as soon as September. Being 37 and based on those stats I was expecting 4-5, not the 22% we got. J Assist Reprod Genet. In a small study,Bradley et al. Use of this site is subject to our terms of use and privacy policy. All content and information on this website are for informational and educational purposes only. At age 38, I had 5 blastocysts and only 1 was PGS normal. Embryos end up with an abnormal number of chromosomes because the egg has abnormal chromosomes, or the sperm has abnormal chromosomes or during the first cell division after fertilization, the chromosomes are inappropriately separated. There are three different types of preimplantation genetic tests, each looking at three different things: PGT-A, PGT-M, and PGT-SR. PGT-A is the most common form of preimplantation testing and it looks for something called aneuploidy. Find advice, support and good company (and some stuff just for fun). I know how hard it is. I know how you feel, but it's awesome you got 2. ttc 1 year, 1st ivf, 5 made to day 5. In PGS, a judgment is made about an entire embryo by testing a few representative cells. In women between the ages of 35-38, only about 50% of embryos will be euploid. This decreases the time to pregnancy and increases the likelihood of achieving a live birth as abnormal embryos are more likely to lead to miscarriage. may be contradicted by other studies. How many eggs should I request to fertilize? Thought just because your embryo iseuploidthat grades dont matter anymore? We had transferred one, the ended in a CP. Success rate of IVF First Time: The Likelihood of It? Other patients who benefit from PGS include: It is important to note that PGT is optional, and will add costs to your IVF treatment cycle. Hi I'm I am curious to learn if you chose to do pgs testing what your results were I'm currently awaiting my second round of IVF pgs result. There is an additional cost with the screening as well as risk to the embryos, and therefore it is not something all IVF patients choose. Make an appointment with Dr. Robles to discuss your fertility options today! For more than a decade, we have been screening embryos for chromosomal number abnormalities (aneuploidy) at InVia Fertility Specialists. 2005-2023Everyday Health, Inc., a Ziff Davis company. While the testing occurs, the clinic freezes the blastocysts. (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. In short it suggests (but don't skip they book, it's amazing): I would agree with others that different cycles can have wildly different outcomes and that the first cycle can often be the most disappointing as the docs figure out how your ovaries work and best respond to meds. Please whitelist our site to get all the best deals and offers from our partners. Embryos with normal PGT results (of any type) can still fail to implant or result in a miscarriage. It's very interesting. Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial. I am out of money and almost out of hope. I guess for me I had 2 other normal embryos but had these mosaics that I didn't want to wonder what if. Thanks everyone, I feel a little less panicked now, it was just not what I was expecting! We were shocked that this could happen at age 32 with no explanation. For the last round, I ate a higher protein diet ( esp plant based proteins), organic foods, Omegas, etc. The PGS/PGD results determine whether or not an embryo has a normal number of chromosomes. We see the doc on Monday so I'll be really interested to know what was "abnormal" about the other 6. Note that once you confirm, this action cannot be undone. Patients often hear PGS-normal embryos have a 60 70% success rate. Some clinics have extremely high IVF success rates. Continuing with the normal IVF process, an embryologist fertilizes the egg with sperm collected from the womans partner or with donor sperm. Dx: Mild Endo, Immune Related Issues, Unexplained. And for someone that was willing to donate to a friend you really really deserve it! Out of any normals, we will take the doctors advice on what to use first. Hey Peg, In a woman under age 30, about half of embryos are aneuploid. I had 13 blasts tested from 3 cycles. We sent the best 8 for testing. The frequency of normal cells found in these embryos varied between 54.5 and 80%. If it does, the embryo can be used in the embryo transfer process and may increase IVF success. It will involved thawing your embryos, biopsying, then re-freezing and ultimately re-thawing if the embryo is euploid and you want to transfer it. I wanted to see if those could be tested now, but I think that it's too late? Although I strive to provide accurate general information, the information presented here isnot intended for the prevention or treatment of infertility and it isnot a substitute formedical or professional advice. Save my name, email, and website in this browser for the next time I comment. Liebermann et al. Your embryos will then be kept in the IVF lab for one week. About 3 out of 4 of these euploid embryos will implant on average (75 percent implantation rate), with high pregnancy rates per transfer. Please re-enable javascript to access full functionality. As the chart below shows, a relatively small percentage of embryos developed during IVF qualify as "chromosomally-normal" or "euploid." He has a special interest in health, lifestyle, & nutrition. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. Further testing - the RPL test- results in suspected immune issues. Diagnosis: Repeated Pregnancy Loss + DOR + Advance maternal Age. Ten years ago, day-three embryos were routinely transferred in IVF cycles. I will also continue acupuncture. Therefore, women over the age of 35 may wish to consider PGT-A testing, especially if they have a history of failed implantation or pregnancy loss. Percent euploidy was subsequently assessed by day of blastocyst biopsy (days 5, 6, or 7) for each SART age category (Fig. Hi, i know this is an old post but thats what happening to me. So what if the embryos are euploid? 2019 Jan;36(1):165-172. doi: 10.1007/s10815-018-1322-2. Now we have one PGS tested embryo left and I'm devastated. In women under the age of 35, approximately 60% of embryos will be chromosomally normal. Then I opened my eyes and researched them extensively and spoke to specialists and came to the conclusion that PGS may only be good for those who have a known family genetic abnormalities. Because of this, women fertility clinics can reduce the likelihood of miscarriage through PGS/PGD, that is great news. 20 eggs retrieved 17 mature 5 frozen 10 of 12 fertilized w/ ICSI 10 5day blasts sent for PGS 4 normal embryos Since we have been performing PGT-A on blastocysts (day 5 or 6 embryos) at our Newport Beach fertility center, we have found the accuracy of the procedure to be greatly improved. I am 43 and just did my first round of IVF, egg retrieval, had 8 PGs all 8 came back abnormal. Sometimes, an embryologist will remove cells prior to blastocyst phase. So far HCG is doubling properly Good luck! I had read and researched on abnormal embryos autocorrecting in the uterus and went with my gut. PGT-A is very reliable for detecting aneuploidy. The term "recurrent miscarriage" means at least two consecutive pregnancies ended prematurely; this affects between 1% and 3% of all women. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. Instead of seeing two copies of chromosome 21, an embryo with Down syndrome will have three copies (Trisomy 21). This explains why miscarriage rates are significantly higher in women over the age of 40. I have done 4 IVF cycle and so far we had one normal from each cycle. The graph below illustrates what we have discovered. For <37, this was about 5, for 37-40 about 4, and for >40 about 3 (so older women tend to produce fewerblasts). Even my very conservative clinic, who basically will recommend nothing unless there is substantial serious science behind, started recommending a pre-conception multi-vitamin that includes COQ10 but only after we had finished with fertility treatments. The key percentage to factor in is the number not mentioned with PGS testing. In fact, the pregnancy rate from transferring a normal embryo does not exceed 60 to 70%. Best of luck to you! Several studies have concluded that PGT-A can improve your chances of a live birth if you are 35 years of age or older. The normal embryos that are not transferred can continue to be kept frozen for later cycles of IVF, or for embryo donation. While many studies find the risk of miscarriage is lower in embryos with normal PGT-A results compared to untested embryos, especially when the individual providing the eggs is 35 years or older, pregnancy losses can still occur. At 28 years old, approximately 30% of her remaining eggs have chromosomal abnormalities. Nov. 1st - start .5ml buserelin each night. If all goes well, all of the eggs will be fertilized and develop into embryos (2-3 days) and then blastocysts (5-6 days). Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid FZMM 5 yr. ago Unfortunately, chromosomally abnormal eggs will develop into chromosomally abnormal embryos following fertilization. PGT-SR is less commonly used and is usually only done when a specific structural mutation is detected in either parent. All four arrested embryos diagnosed as normal at PGS analysis were shown to be chromosomally overall abnormal. Yes I won't lie when I first had PGS done and heard I had "abnormal" ones i instantly feared oh those are all bad and I would have heart ache and suffering. Out of those 3, 2 were PGS normal, which aligns with statistics for my age (33). I am 7 weeks pregnant from my first FET! In a recent study of 98 women who had mosaic embryos, 32 (33%) elected to have at least one transferred. Then we did a FET, that ended at 8 weeks, a missed mc. But what about the women who didnt get blasts? My gut reaction was that it had to be wrong. 2011(38) : Get married and our son is born. The embryo having an abnormal chromosome number. Obviously this is not an ideal situation but sometimes this happens. An average IVF cycle lasts between 8-12 days. This includes preeclampsia and other hypertensive disorders, and possibly small for gestational age fetuses. https://www.google.com/amp/s/mobile.nytimes.com/2016/04/19/health/ivf-in-vitro-fertilization-pregnancy-abnormal-embryos-mosaic.amp.html. Whitney et al. I started 2 wks into my IFV so this time I hope it helps more since I plan on waiting at least 2 months. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. This is Day 1. Embryo mosaicism is when an embryo contains two or more genetically distinct cell lines. Its unclear why there is an inconsistency with live birth rates, while miscarriage rates are lower. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). The effect of maternal age on the possibility of retrieving at least one normal embryo was similar, with a rapid exponential decline (R2 14 0.986). Hope things take a turn soon. They analyzed the relationship between maternal age and the rate of embryos that tested as euploid, the average number and proportion of normal embryos per IVF cycle and the possibility of retrieving at least one normal embryo. May 2018-May 2019: 6 more IVF cycles.. 12 embryos, 3 PGS normal (5AB, 3AB, 4BC), 1 mosaic (4BB), 1 too small to test (3BC), 7 abnormal. Miscarriage can be tragic, but even more so after going through the time, money, and discomfort of in vitro fertilization treatment. Fertil Steril. Referral to endocrinologist. We strive to provide you with a high quality community experience. I have sent 6 from 3 retrievals and only 1 was normal which we transferred one last week! PGT-A only looks for numerical chromosomal abnormalities. For these groups, about 50% of biopsies had noeuploidembryos. Your clinic may have a better idea of how things work in their hands. At InVia Fertility Specialists, we have been offering SMART IVF (PGD or PGS) for many years. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. I read that between age 35-39 the standard result is 50% normal. One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. Blood tests at the end of July and end of August to see if all is well. PMID: 31551155. Nov-Dec 2015: Freak out that out of almost 50 eggs, only 1, 1! DH and I have talked about it and honestly I don't care either way.